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Massive Acetaminophen Overdose: Are We Giving Enough N acetyl cysteine? St. Joseph's University Medical Center: Emergency Medicine Residency Program Nishith Revappala Why glutathione isn't the antidote Explained though concept chain from Simplify Rx Instagram 10 days of MCQ! Day 3: Acetaminophen Overdose Answer: C N acetylcysteine (NAC) NAC is the antidote for acetaminophen overdose. It works by replenishing hepatic glutathione stores, which are rapidly depleted A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Acetaminophen Toxicity Poisoning YouTube

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