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JBRA assisted reproduction 24:454465

The effect of pycnogenol supplementation on plasma C-reactive protein concentration: a systematic review and meta-analysis

A pivotal RCT in 116 cannabis-dependent adolescents found that NAC (1,200 mg twice daily) more than doubled the odds of a negative urine cannabinoid test compared to placebo (OR 2.4, 95% CI 1.1-5.2) (Gray et al., Am J Psychiatry, 2012) [76]