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Leslie Kux, FDA, states repeatedly in the 2015 response that FDA also believes that even though amalgam patients with numerous amalgam-filled surfaces could be exposed to daily doses of mercury vapor above the available RELs, this alone does not necessarily indicate that adverse health effects from dental amalgam will occur. These types of statements clearly elucidate that Leslie Kux and the FDA choose to ignore the essence of why RELs are established, why they are important, and why they must be followed

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Interestingly, Anmella et al

Chromatin immunoprecipitation showed that Cited2 and Smad3 were recruited to MMP9 promoter upon TGF- stimulation

Therefore, prolonged deficiency in one or more micronutrients leads to cardiovascular or neurodegenerative disorders