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An artifact in LC-MS/MS measurement of glutamine and glutamic acid: in-source cyclization to pyroglutamic acid

Indeed, LDHB silencing resulted in a significant increase in mitochondrial lipid peroxidation not only in the NSCLC cell line A549, the malignant pleura mesothelioma (MPM) cell line MSTO-211H, the fibrosarcoma cell line HT1080, and the pancreatic ductal carcinoma cell lines PANC-1 (Fig