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Follow a Balanced Diet Including sufficient amounts of animal-based foods such as eggs, dairy, meat, and fish helps maintain adequate B12 levels

Nucleic Acids Res 43:D837D843 Ulapane KR, Kopec BM, Moral ME, Siahaan TJ (2017) Peptides and drug delivery

The reason is physiological, not arbitrary

The CIRCORT database: Reference ranges and seasonal changes in diurnal salivary cortisol derived from a meta-dataset comprised of 15 field studies by Miller et al , in Psychoneuroendocrinology , Nov 2016 , 73, pages 16-23

however, taking iron tablets with acid reflux can be challenging because iron can irritate the stomach lining and worsen reflux symptoms if taken on an empty stomach or without medical guidance