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1 ENTYVIO trough levels with the SC and IV formulation 15 ENTYVIO IV ENTYVIO SC Placebo At steady state*, ENTYVIO showed Consistency The drug trough levels for the ENTYVIO Pen were consistent Stability The ENTYVIO Pen provided drug trough level stability for patients No loss Transitioning to maintenance therapy with the ENTYVIO Pen did not lead to lower trough levels Observed median and interquartile range trough concentrations (C trough ) by study visit, presented on a semi-log scale (y-axis)

However, the effects of antioxidants (vitamin C, etc.) in OIPN require further clinic tests and verifications

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Insulin-like growth factor-1 (IGF-1) improves both neurological motor and cognitive outcome following experimental brain injury

Overall, these studies indicate that NRF2 activation is required to protect against DN and that the development of more NRF2-specific inducers with fewer off-target toxic effects is needed to delay diabetes progression and the onset of diabetic outcomes