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We and others have recently shown that the distribution of intrinsic disorder propensity within the amino acid sequence of mature IGF-1 is markedly different compared to E-domains 5,13

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In preclinical data, the pair improves adipocyte NAD+ by inhibiting NNMT, resulting in better fat metabolism and reduced obesity.[8][3] For anti-aging, this translates to improved tissue resilience and reduced senescence

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