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PMID: 40915186 Int J Mol Sci HER2-Driven Breast Cancer: Role of the Chaperonin HSP90 in Modulating Response to Trastuzumab-Based Therapeutic Combinations

International Journal of Biological Macromolecules, 107 , 748754

Depending on the active site structure, Grx isoenzymes can be dithiol or monothiol (active site sequences Cys-X-X-Cys and Cys-X-X-Ser, respectively) [147]

2018, 2019), lithiated cobalt oxide nanosheets (Ostovich et al

62 AP-1 and MAPK synergistically upregulate the transcription of matrix metalloproteinases, 63,64 which degrade the follicular basement membrane (eg collagen type IV) and extracellular matrix (ECM), weakening the mechanical stability of the hair follicle and leading to follicular rupture