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In addition, treatment with coumarins isolated from Hydrangea paniculata improved colonic integrity, decreased the Firmicutes-to-Bacteroidetes ratio, reduced the relative abundance of Allobaculum and Desulfovibrio , decreased uremic toxin precursors, and enhanced SCFA production in MN rats [136]

Aflatoxin B1 impairs sperm quality and fertilization competence

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Conclusion: These studies reveal that deletion of the BA etiologic gene Pkd1l1 leads to increased expression of pro-inflammatory mediators in mouse cholangiocytes, both basally and in response to LPS

352 A bisubstrate inhibitor comprises two covalently linked fragments, each binding to a substrate or cofactor element, potentially mimicking the ternary transition state of a bireactant-catalyzed reaction