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( a ) Relative cell number of SEM, NALM6 or MOLT16 cells expressing RFP or AOX and treated with vehicle or Antimycin A (5 nM) for 3 days

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Rarely, if the nodule is very large, the patient may also develop symptoms due to the enlarged thyroid gland such as difficulty with breathing or swallowing (as the enlarged gland may press on the food or wind pipes, which are located nearby)

A null polymorphism in NQO1 15,16 has been associated with an increased risk of complications related to metabolic syndrome 17,18 and NQO1-null mice develop insulin resistance resulting in a T2D-like phenotype 19