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Disruption of this microbiome-host symbiosis contributes to the initiation and progression of immune and metabolic diseases, such as IBD 73 , graft-versus-host diseases (GvHD) 74 , and type 2 diabetes 75 , underlining the proposition that microbe-host interactions are critically important for human health 76

Furthermore, patients with inflammatory bowel disease have a higher risk of HHcy due to vitamin B deficiency

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The profound function of H 2 0 2 is illustrated by catalase, which restores the spontaneous induction of tyrosine phosphorylation in capacitating mammalian spermatozoa, and hence, reduces functions, such as hyperactivation, acrosomal exocytosis, and sperm-egg fusion