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Analysis of this revealed an extensive hydrophobic interface formed by V13, L14, L17 and V21 (the H1-2 alpha helix) which mediated CARD domain oligomerisation (Figure 3A)

Treesinchai et al., Determination of curcumin stability in various gastrointestinal pH by Arrhenius equation using HPLC method Medicine, Materials Science 1 February 2016 15