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In extreme scenarios, like those tied to iron deficiency, it may lead to further red cell damage, amplifying symptoms

In head and neck squamous cell carcinomas (HNSCCs), CDKN2A expression is significantly higher in stage T2 tumors compared to stages T3 and T4, suggesting higher expression in early malignant tumors and lower expression in advanced cancers

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The loss of redox homeostasis generates stressed cells which in turn produce damage-associated molecular patterns (DAMPs) or autoantigens that could initiate innate immunity and adaptive immunity