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Aberrations in multiple molecular pathways contribute to the development and progression of AD pathology including tau hyperphosphorylation, DNA hypomethylation, and maladaptive neuroinflammation (3)

HMGA1 is a major transcription factor that amplifies HK2 in pathological conditions The Human Protein Atlas (HPA) RNA-sequencing data indicate that HK2 is not enriched in the liver (Supplementary Fig