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doi: 10.1210/jcem.83.9.5125

Piazza explains further why he recommends using these three supplements to all his surgical patients: Post-Surgery Supplement Protocol When to Resume Taking Supplements After Surgery While its important to follow your surgeons instructions on the day of your procedure, it's perfectly fine to pause these supplements for the day of surgery

1-2 months: You may start to see some improvements in skin texture and a slight fading of dark spots

Pharmacological reduction of oxidative stress by administering Trolox, a water-soluble antioxidant and vitamin E analog, also partially rescued DNA damage and cellular toxicity in Drosophila expressing C9orf72 DPRs (Lopez-Gonzalez et al., 2016)

Both options have advantages and disadvantages, and the effectiveness of each treatment will depend on the individual's skin type, lifestyle, and budget