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The dosage is escalated by adding 2.5 mg to the existing dosage every 4 weeks

Collectively, these late effects illustrate the narrow therapeutic window inherent to brachytherapy: the difference between a curative dose and the threshold for debilitating toxicity is small, particularly in patients with complex pelvic anatomy or advanced disease

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Of importance, androgen ablation is the mainstay of therapy for progressive prostate cancer