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In conclusion, oxidative stress acts as a catalyst for deterioration of AD by augmenting MMP activation, thereby reshaping the ECM and aggravating degradation and remodeling of aortic wall

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While some researchers argue that even low levels of neurogenesis may contribute to cognitive functions such as memory and mood regulation, others argue that the absence of significant neurogenesis in adults may limit the brains capacity for self-repair and adaptation [205,206]