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This metabolite targets the colonic -aminobutyric acid transporter 3 (GAT-3), initiating the GAT-3/RAR/RORt signaling axis, ultimately inhibiting the differentiation of pro-inflammatory Th17 cells ( 6.2.3 The impact on intestinal tumors Recent studies have found that silybin has different regulatory effects on normal intestinal epithelial cells and intestinal tumor cells, showing protective effects on healthy cells and inhibitory effects on tumor cells ( In normal intestinal epithelial cells (such as the IPEC-1 cell line), silybin can promote cell metabolic activity and proliferation, protect the integrity of the mitochondrial membrane, thereby exerting a cytoprotective effect

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10.3389/FIMMU.2017.00531 97 KhanA.AliT.RehmanS