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While this usually improves over time, it can contribute to ongoing discomfort if not monitored

Quintanilla ME, Rivera-Meza M, Berrios-Carcamo PA, Bustamante D, Buscaglia M, Morales P, et al

F., Lesan, A., Puiu, R., Lucaciu, S.-R., Dantes, E., & Gergely-Domokos, B

Additionally, no clear evidence exists for its benefit to patients with EPI.28 Micronutrient Needs in Pancreatic Insufficiency Patients who have signs of micronutrient/vitamin deficiencies, inadequate intake, or prolonged malabsorption should be assessed

While the majority (67.7%) of rhythmic transcripts in at least 1 genotype demonstrated unaltered rhythm (system-driven transcripts), 16.7% of transcripts lost their rhythmicity in cKOt mice (BMAL1-driven transcripts), 9.2% gained rhythmicity (transcripts that became rhythmic after the deletion of Bmal1 ), and 6.4% exhibited altered rhythm (BMAL1-modulated transcripts) (Figure 1B and Supplemental Figure 1B)