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The lower availability of SAMe may be related to the altered expression of genes involved in APP metabolism, finally producing the accumulation of A peptide, contributing to the pathological processing of AD [6, 140]

however, structural comparison of TYRs ( jr PPO1 26,27 , Md PPO1 16,24 Ab PPO3 28 and Ab PPO4 29 ) and COs ( Ib CO 22 , Vv PPO 23 and cg AUS1 25 ) revealed no considerable differences (Table S1)