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In fact, the GPx4 protein itself possesses a number of cysteine residues on its protein surface, which have been implicated in its ability to form extensive enzymatically inactive protein polymers (Scheerer et al., 2007)

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For example, HF individuals with reduced ejection fraction are generally advised against participating in competitive sports, while those with HF and preserved ejection fraction, classified as low-risk, may engage in certain competitive activities

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