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Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: A randomised, single-blind, placebo-controlled, phase 1 trial

As all data to identify the individual patients were anonymized and deidentified for analysis, the institutional review board waived the need for informed consent

B 11 , 340354 (2021)

In rats treated with Splenda (Heartland Consumer Products, Carmel, IN, USA) (the commercial formulation of sucralose, containing 1.1% w/w sucralose plus maltodextrin and glucose), faecal counts of total anaerobes increased, whereas the numbers of bifidobacteria, lactobacilli, Bacteroides , clostridia and total aerobic bacteria decreased

FIGURE 1 2 Preparation methods 2.1 Extraction methods Royal jelly acid can be extracted from royal jelly through several methods, including ethanol extraction (Iegaki, et al., 2020), ether extraction (Wang, et al., 2006), solution precipitation crystallization (Wang, et al., 2006), reverse phase column chromatography (Pandeya, et al., 2019) and adsorption method (Zhang and Yang, 2014)