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While most of the drug is conjugated via glucuronidation and sulfation, a small fraction is oxidised by cytochrome P450 enzymes especially CYP2E1 into N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive and hepatotoxic compound

Hence, prolonged IGF-1 or IGF-1 gene therapy could disrupt the nuclear p53progerin interaction to repress oxidative SIPS via activating the PI3K/AKT1 pathway and inhibiting p53 nuclear translocation

Wang J, Zhu W, Li X, Wu Y, Ma W, Wang Y, Zhao W, Wei F, Wang W

Earlier studies showed that deletion of RAGE improved pain perception in diabetic mice [51]

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