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Clin Cancer Res 23(18):56395647 Ramirez-Pea E, Arnold J, Shivakumar V et al (2019) The epithelial to mesenchymal transition promotes glutamine independence by suppressing GLS2 expression

Muscle-specific deletions of mTOR 354 or Raptor 355 lead to progressive muscle dystrophy, diminished oxidative capacity, and glycogen accumulation, despite hyperactivation of AKT caused by disruption of mTORC1 feedback inhibition, which is mediated through S6K1IRS1 signaling