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In addition, CoQH could not only indirectly promote the the fat-soluble antioxidant -tocopherol to regenerate but also cooperate with it to scavenge free radicals and inhibit ferroptosis (Wang Z

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Since each drug of abuse has a different mechanism of BBB disruption, understanding the effect of polysubstance abuse on BBB could allow the evaluation of novel therapeutic agents and systemic prediction of clinical efficacy