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210 Gonadotropin therapy has been found to increase the odds of successful birth by 1328% in women with PCOS who did not become pregnant using clomiphene citrate

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KDIGO defines initial hyporesponsiveness as having no increase in hemoglobin concentration after the first month of appropriate weight-based dosing, and acquired hyporesponsiveness as requiring two increases in ESA doses up to 50 percent beyond the dose at which the patient had originally been stable