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Kidney-targeted delivery systemssuch as PEGylated lipid nanoparticles (LNPs) modified with renal tubular cell-targeting ligands (e.g., vitamin B12, which binds to cubilin on PT cells)have shown promise in preclinical studies, increasing renal Fer-1 accumulation by 510-fold and reducing systemic toxicity

Alteration of thyroid homeostasis by UDP-glucuronosyltransferase inducers in rats: a doseresponse study

The molecule does not survive stomach acid well, and most of what does survive is broken down in digestion before reaching circulation

Best tests to determine B12 deficiency & need Methylmalonic Acid (MMA) Homocysteine Active B12 (Holotranscobalamin - holoTC) If both the MMA and Homocysteine test results are high, then you may not be getting enough B12 intracellularly (even if your blood serum tests show B12 as high) Unfortunately most medical professionals test for B12 sufficiency using a blood serum test