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Reduced autophagic flux can lead to dysfunctional organelle accumulation, increasing oxidative stress and ferroptotic sensitivity (79)

When autophagy is initiated, an isolated membrane structure called a phagophore is formed at a special region associated with the endoplasmic reticulum (ER), Golgi apparatus, and ERGolgi intermediate compartment 20,21,22

Guiscafre-Gallardo, S

Substitution of cysteine for a conserved alanine residue in the catalytic center of type II iodothyronine deiodinase alters interaction with reducing cofactor