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Without sesame oil, low thyroid status was associated with higher LDL cholesterol in the plasma and lower LDL receptors in the liver, whereas treated hypothyroid rats reaching normal thyroid status had lowered plasma LDL cholesterol and higher hepatic LDL receptors

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Subsequent investigations revealed that c9,t11-CLA effectively suppresses the expression of pro-inflammatory factors, chemokines, and ICAM-1 by inhibiting NF-B transcriptional regulation and dampening MAPK signaling pathway activity, thus exhibiting potent anti-inflammatory properties