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Anhedonia, the loss of interest in pleasurable activates, is often a symptom of major depression along with low self-esteem, lack of energy, and pain without any clear cause 31

Conventional DMARDs (e.g., methotrexate, leflunomide, sulfasalazine): Methotrexate slows joint damage and suppresses inflammation but causes hepatic toxicity and bone marrow suppression, leading to 30% treatment discontinuation within one year (8)

Its critical role as a detoxifying agent and free radical scavenger makes it a master antioxidant .* The glutathione level can decrease in our body due to several factors, including aging, poor diet, lifestyle choices, and certain pathological conditions

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In contrast, epithelial heights of cauda epididymis increased, and that of the caput remained unchanged