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HNE 4-hydroxy nonenal the LOOH product, HNE induced significant tissue injury and apoptosis

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Arginine salt (arginate) form shows dramatically improved oral bioavailability (over 90% versus about 3% for acetate) due to enhanced gastric stability

In addition to glycolysis, KEGG enrichment revealed glutathione metabolism pathway as one of essential pathways that mediate induced stress tolerance (Fig