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It is the main consumer of NAD + in aged tissues its activity increases significantly after age 40

Proc.Natl.Acad.Sci.U.S A

NAD-MDH usually exists in the cytoplasm and mitochondria of bacteria and eukaryotic cells

doi: 10.1016/j.semcancer.2005.07.004 57 PereiraMDursoDFBryantCEKurt-JonesEASilvermanNGolenbockDTet al

Eases Muscle Tension: Magnesium's muscle-relaxing properties help alleviate muscle cramps, spasms, and general restlessness that can disrupt sleep, allowing for a more comfortable nights rest [NIH]