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Compared to other forms of BC, TNBC exhibits a lower overall survival (OS), a higher rate of distant metastases, and a higher rate of recurrence [2, 3]

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Along with the process of -GC synthesis was blocked by BSO, the total contributions of U- 15 N glutamine to GSH was reduced in the established high ACTL6A-expressing PDX tumors, and the levels of [ 15 N]-labeled glutamine and glutamate were thus increased (Fig