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10.1002/jcp.25818 55 LiuG

CZ revised the review

In conclusion, although TAM acts effectively as an anti-breast cancer drug, the oxidative DNA damage induced by a TAM metabolite shown in this study may be tumor-initiating, and coupled with the cell proliferation (tumor promotion) induced by TAM and its metabolites as revealed in the references, may contribute to the development of endometrial carcinogenesis