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The initiation and progression of AD is characterized by disturbances in intracellular proteostasis due to the alteration of protein synthesis, folding, surveillance, and degradation, which trigger the accumulation of altered proteins and toxic aggregates, widely recognized to be implicated in this phenomenon (327, 330332)

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Time kill-kinetics assay Bactericidal activity is defined as a higher than 3 log 10 fold decrease in colony forming unit (99.9 killing of the starting inoculum)

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Early response to antipsychotic therapy as a clinical marker of subsequent response in the treatment of patients with first-episode psychosis