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Cancer-cell-derived GABA promotes -catenin-mediated tumour growth and immunosuppression

Including clinically diagnosed cases alongside genetically confirmed patients enhances the real-world representativeness of this review but introduces diagnostic heterogeneity and potential misclassification, which may limit the generalizability of treatment-related conclusions, particularly regarding the efficacy of oral vitamin B12 therapy

and track standardized outcomes (pain, function, mobility, gut symptoms) over time

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Therefore, there is a significant need to investigate the efficacy of complementary and alternative therapies and their tolerability in children with ASD while also identifying those that respond to these interventions