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The promised results are more than a little appealing: increased energy, stamina, body detoxification, and clearer, brighter skin

Heres an honest look at what the research shows, where the evidence is strong, and where its still early

Informed consent

The full effect can take 12 weeks or longer, depending upon how well you tolerate the medicine

Other classes of medications that have been effective in controlled clinical trials include trycyclic antidepressants and related agents (e.g., amitriptyline, cyclobenzaprine) [22, 23], mixed serotonin/norepinephrine reuptake inhibitors (e.g., duloxetine) [24], dopamine agonists (e.g., pramipexole) [25], and the sedating hypnotic sodium oxybate [26]