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Additionally, an external magnetic field promotes their in vivo targeted accumulation ( 3.2 Vascular intervention and thrombosis treatment In the realm of vascular intervention, beyond thrombus clearance, nanorobots demonstrate significant potential for intraoperative hemostasis and modulation of the vascular microenvironmentfor instance, through the targeted delivery of thrombin for precise hemostasis or the mitigation of ischemia-reperfusion injury (Figure 3A)

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doi:10.1016/j.jri.2024.104219

This discovery was made available to researchers

1 Introduction Despite decades of intensive research and substantial investmentwith Alzheimers disease alone projected to surpass 1 trillion USD in global cost by 2050 (Nandi et al., 2024), therapeutic progress in neurodegenerative disorders has remained limited, with most clinical approaches continuing to target downstream proteinopathies and yielding only modest effects on disease trajectories (Selkoe and Hardy, 2016