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This two-phase process is critical to the malignant transformation of the epithelial cells

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The following serious adverse reactions are described, or described in greater detail, in other sections: Addiction, Abuse, and Misuse [see WARNINGS] Life-Threatening Respiratory Depression [see WARNINGS] Neonatal Opioid Withdrawal Syndrome [see WARNINGS] Ultra-rapid Metabolizers of Codeine [see WARNINGS] Interactions with CNS Depressants [see WARNINGS] Severe Hypotension [see WARNINGS] Gastrointestinal Adverse Reactions [see WARNINGS] Seizures [see WARNINGS] Withdrawal [see WARNINGS] Opioid-Induced Hyperalgesia and Allodynia [See Warnings] The following adverse reactions associated with the use of codeine were identified in post marketing reports