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Measurement of the rate of copper(II) exchange for 64 Cu complexes of bifunctional chelators

unmodified form Distribution and Elimination: Plasma half-life comparison to standard Epitalon (hypothesis: extended) Tissue distribution patterns under investigation Metabolic stability assessment in plasma and tissue homogenates Renal clearance characteristics Cellular uptake and retention studies Biological Activity Timeline: Comparative time-course studies with Epitalon Assessment of sustained vs

Single-cell sequencing analysis revealed that the deletion of METTL1 specifically inhibited the differentiation of a fibroblast subpopulation towards a pro-fibrotic phenotype, whereas no significant effects were exerted on cardiomyocytes or on other cardiac resident cells