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In general, ECs are connected side-by-side through transmembrane adhesion proteins [37], including vascular endothelial and neural cadherin at adherent junctions [38, 39], occludin [40], and members of the claudin family [41], as well as the junctional adhesion molecule (JAM) family at tight junctions [42]

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At the same time, GSH boosts anti-inflammatory molecules like IL-10 and regulates pathways, such as PTEN/PI3K/AKT, to reduce inflammation in conditions like rheumatoid arthritis (4)