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Key Takeaways MOTS-c activates AMPK to increase fat oxidation and mitochondrial biogenesis, with a half-life of 46 hours requiring multiple weekly doses

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In 2021, the numbers of AAF were 33% from SERMs (tamoxifen and clomiphene) and 15% from AIs (anastrozole, letrozole, adrostatrienedione, armistane, and 2-androstenone) (World Anti-Doping Agency, 2024a)