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Yu D, Liu Y, Zhou Y, et al

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however, other forms of ROS also contribute as the nitric oxide (NO) generated by NO synthases, which diffuses into mitochondria and modulates mitochondrial function by competing with O 2 at respiratory complex IV thereby slowing respiration (Collins et al., 2 O 2 in thiol oxidation modulating the function of proteins (Collins et al., The protection available for cells under oxidative stress comes from natural antioxidants and several antioxidant enzymes (Davies, 1997)

In NDDs, chronic mtDNA-driven NLRP3 activation in microglia fuels sustained neuroinflammation, linking mitochondrial dysfunction directly to neuronal injury and disease progression