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Tsuda 1999

When activated by stress-induced hormonal imbalances, these pathways promote the production of pro-inflammatory cytokines and genes associated with oxidative stress, increasing the overall oxidative burden on cells (53)

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The adoption of the PCPA-induced insomnia model in mice has enabled researchers to delve into the molecular mechanisms underlying sleep regulation (Hong et al., 2020), exploring the intricate interplay of cytokines (Wang et al., 2022), neurotransmitters (Lv et al., 2021), and their receptors