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Observational and preclinical studies were retained for mechanistic insights but assigned lower levels of certainty in clinical translation

Conversely, when substrates upstream of GAPDH are limited, glycolysis is primarily regulated by other upstream rate-limiting enzymes [53]

doi: 10.1534/genetics.118.301628

This can impair protein function, as evidenced by inhibition of enzyme activity, impaired histone-DNA binding, and inhibition of polymerization of tubulin