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Description

Alleviative effects of -lipoic acid on muscle atrophy via the modulation of TNF-/JNK and PI3K/AKT pathways in high-fat diet and streptozotocin-induced type 2 diabetic rats

In contrast to the placebo-treated subjects who experienced minimal changes in body weight over the 16-week treatment period, the pramlintide-treated subjects attained significant weight loss from baseline as early as week 2, which was progressive up to week 16, with no evidence of a plateau