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After a week-long regimen of oral broad-spectrum antibiotics to suppress the intestinal microbiota, the oral l-carnitine challenge was repeated (+ Abx, open circles)

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If an individual lacks a functional liver enzyme called FMO3, they cannot degrade TMA into a non-smelly chemical form, trimethylamine oxide, or TMAO

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For verification, we prepared samples combined with betaine (BT), polyquaternium-51 (PQ), or HSC as hydrophilic small molecular, hydrophilic polymeric molecular, and amphiphilic molecular zwitterionic counter ions, respectively