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1331-C UNLEASHING THE POWER OF HBV QUASISPECIES CHARACTERISTICS: ENHANCING HCC PREDICTABILITY IN HBEAG-POSITIVE CHRONIC HEPATITIS B PATIENTS WITH REACH-B SCORE INTEGRATION Chih-Jen Huang 1 , Mei-Hung Pan 1 , Rachel Wen-Juei Jeng 2 , Yin-Han Chou 1 , Pao-Chun Hsu 1 , Ching-Yu Bao 1 , Wenya Huang 3 , Shiou-Hwei Yeh 4 , Pei-Jer Chen 5 , Chien-Jen Chen 1 , Zhiwei Liu 6 and Hwai-I Yang 1 , (1)Genomic Research Center, Academia Sinica, (2)Linkou Chang Gung Memorial Hospital, (3)College of Medicine, National Cheng Kung University, (4)College of Medicine, National Taiwan University, (5)National Taiwan University Hospital, (6)National Cancer Institute Background: Hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC)

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