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Your immune system spots these MSU crystals through Toll-like receptors (TLR) 2 and TLR4 [1]

10.1002/ptr.7928 103 LiuX.ZhangY.WuX.XuF.MaH.WuM.et al (2022b)

For instance, aged mice have microglia with increased levels of the nod-like receptor protein 3 (NLRP3) inflammasome (Youm et al., 2013)

When glutathione levels decrease, for example, due to stress or nutritional deficiencies, the risk of catching a cold, getting infections, feeling constantly fatigued, or experiencing sleep disturbances significantly increases

In another study, it was shown that Epitalon had an effect on macrophages depending on the age of mice from which the cells were collected