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Correlation analysis of the transcriptome and lipidomics showed that the differential gene hormone-sensitive lipase-like ( HSL ) was positively correlated with various lipids [triglycerides (TG), phosphatidic acid (PA), phosphatidylserine (P), phosphatidylethanolamine (PE), glucosylceramide (GlcCer), phosphatidylglycerol (PG), and phosphatidylinositol (PI)] but was negatively correlated with diacylglycerol (DG), lysophosphatidylethanolamine (LPE), and sphingomyelin (SM)

Fan W, Chen H, Li M, Fan X, Jiang F, Xu C, et al

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IGF can alter and enhance the sensitivity of theca or granulosa cells to stimulation of gonadotropin, and thus regulate the secretion of sex steroid, and liberation into follicles, finally leading to cell growth enhancement s paracrine/autocrine steroidization factors

Thus, targeting CYP2E1 or activating ALDH2 with safe chemicals, including naturally occurring dietary supplements [334], is a promising strategy to prevent alcohol-induced HCC